Abstract
Along with physical, biological, and mental vulnerability, the existential vulnerability of human beings must be addressed. Iatrophilosophy, a translational discipline between philosophy and medicine, would be competent in this. The problems of the classical meaning of the 'mind-brain problem' (MBP) are analysed and the 'brain-mind postulate' (BsMP) is proposed as an alternative, according to which in endogenous psychoses there would be a polarization of meaning towards meaning (logopathies) or towards the reference (thymopathies).
Keywords: enactivism, philosophy of mind, neurophenomenology, psychiatry, ontosemantics.

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